Spravato (Esketamine) is an advanced nasal spray treatment specifically developed for adults with treatment-resistant depression (TRD) and major depressive disorder (MDD). It is intended for individuals who have not experienced sufficient relief from at least two other antidepressant medications. Unlike traditional therapies that primarily target serotonin or dopamine, Spravato works through a different pathway in the brain to deliver faster results. This makes it a powerful alternative for patients who feel stuck or discouraged by conventional options.
Administered in a controlled clinical setting, Spravato treatment involves a series of sessions supervised by trained healthcare professionals. The treatment plan includes a thorough evaluation, personalized dosing, and continuous monitoring to ensure safety and effectiveness. Most patients begin to feel some degree of symptom relief within hours to a few days of treatment. This rapid response can be a turning point for those battling long-standing or severe depressive symptoms.
Spravato’s active ingredient, Esketamine, is a derivative of ketamine and functions by modulating NMDA receptors in the brain. This mechanism increases the availability of glutamate, the brain’s most abundant excitatory neurotransmitter, which plays a critical role in learning, memory, and mood regulation. By enhancing glutamate activity, Spravato helps form new neural connections, improving brain function and emotional balance. This distinct approach allows Spravato to work more quickly than standard antidepressants.
Because it acts differently from traditional medications, Spravato may also help improve co-occurring mental health conditions like anxiety, PTSD, and OCD. Many patients report feeling more emotionally flexible and mentally resilient after just a few sessions. Its unique ability to “unlock” difficult thought patterns may lead to breakthroughs in therapy and personal insight. Overall, Spravato helps patients reconnect with themselves and move forward with renewed hope.
Why Choose Our Spravato Treatment Services
Your treatment begins with a comprehensive consultation, where your provider will review your medical history and explain how Spravato works. If you’re a good candidate, they will outline the treatment schedule and check your insurance benefits before scheduling your first session. Education on potential side effects and expected outcomes is provided so you feel informed and confident. All questions are addressed prior to beginning therapy.
During each session, you’ll self-administer the nasal spray while being closely monitored in a quiet, comfortable space. Over the next two hours, your healthcare provider will check your blood pressure and monitor how you’re feeling. Many patients describe the experience as calming, dreamlike, or meditative, and most side effects such as dizziness, nausea, or dissociation fade within that time frame. After the session, you’ll need someone to drive you home.
The typical protocol involves two treatments per week for four weeks, followed by a tapering schedule based on your progress. Your provider will adjust the frequency as needed to maintain positive results while minimizing risks. Long-term planning and mental health support are part of the process to help you stay well beyond the initial treatment phase. Spravato offers not just symptom relief, but a path toward lasting emotional recovery.
To schedule any appointment, please submit a request through our website or email us directly at frontdesk@summithealth360.com. A member of our team will contact you to confirm availability and finalize your appointment. Forms are not available online but can be sent by email upon request or completed in-office before your visit.
Take a few moments to fill out a comprehensive health questionnaire covering your medical history, current fitness level, and nutrition habits. The details you provide help us create a customized plan tailored to your unique needs and goals. This also gives our specialists insight into any specific challenges, allowing them to offer guidance that is both practical and effective.
During this session, our health experts review your questionnaire responses, discuss your health objectives, and develop a roadmap for your wellness journey. This is a collaborative effort where every question is addressed, and every concern is taken into account, ensuring a comprehensive and supportive experience.
Patient Testimonials
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Great doctors with helpful attitudes. Use mostly the chiropractor services and pain management. Another benefit is that there is a Quest diagnostic center right next door and they are conveniently located right off the 101 freeway. Never long wait times and easy to make an appointment with efficient and courteous personnel.
— Louis Zeldin.
What Sets Spravato Apart
We know that beginning a new treatment can raise many questions. Here, we have provided answers to some of the most frequently asked questions regarding Spravato therapy. Our goal is to address common concerns and help you navigate the process with confidence, ensuring that you have a clear understanding of the benefits and procedures involved.
During your initial consultation, your provider will review your full medical and psychiatric history, perform a physical exam, and order any necessary tests. They’ll also explain how Esketamine works, discuss potential risks and benefits, and answer any questions to ensure it’s a safe and appropriate option for you.
Unlike traditional antidepressants that target serotonin, dopamine, and norepinephrine, Spravato increases glutamate—a powerful brain chemical involved in communication between nerve cells. This action can produce a faster and broader impact on mood and cognition.
Spravato is self-administered as a nasal spray under direct supervision in a certified clinical setting. You’ll be monitored for at least two hours for safety and comfort before being allowed to go home.
The most common side effects include sleepiness, nausea, elevated blood pressure, dissociation, and a bad taste in the mouth. These typically appear within the first one to two hours after administration and are closely monitored by your care team.
Treatment plans typically begin with twice-weekly sessions for the first month, then taper to once-weekly or as needed based on your progress. Your provider will tailor the schedule to your unique response and mental health goals.
Yes. Many patients report improvement in conditions such as anxiety, PTSD, and OCD as their depression symptoms improve. This is often described as a “rising tide” effect, where relief from depression supports broader emotional healing.
Yes. Many patients report improvement in conditions such as anxiety, PTSD, and OCD as their depression symptoms improve. This is often described as a “rising tide” effect, where relief from depression supports broader emotional healing.
